dc 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10970	DC1		Others
	DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065.		Others
T9978	Glutathione synthesis-IN-1		Others
	Glutathione synthesis-IN-1 (DC-1) is a inhibitor of glutathione synthesis[1].		Others
T15080	DC-05		DNA Methyltransferase , Histone Methyltransferase
	DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).		DNA Methyltransferase , Histone Methyltransferase
T73288	DC-BPi-03
	DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .
T41257	SJ6986		Others
	SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1].		Others
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T70537	DC 015
	DC 015 is a novel potent and selective alpha 1-adrenoceptor antagonist.
T74796	PROTAC GPX4 degrader-1
	PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1].
T36754	DMT-dC(bz) Phosphoramidite
	DMT-dC(bz) Phosphoramidite is typically used in the synthesis of DNA[1].
T61314	DC-CPin7
	DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1].
T63859	DNMT3A-IN-1
	DNMT3A-IN-1 is a selective and potent DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A with a KI ranging from 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).
T61871	DC-LC3in-D5
	DC-LC3in-D5 is a chemical compound that functions as an autophagy inhibitor by diminishing the process of LC3B lipidation. It forms a binding association with LC3B, disrupting the LC3B-LBP2 interaction with an IC50 of 20...
T61719	DC-CPin711
	DC-CPin711, a potent and selective inhibitor of the bromodomain of CREB-binding protein (CBP) with an IC50 of 0.0626 μM, effectively halts the cell cycle at the G1 phase and promotes apoptosis [1].
T78142	DC-BPi-11 hydrochloride		Epigenetic Reader Domain
	DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-proliferative effects on leukemia cells [1].		Epigenetic Reader Domain
T75269	DMT-5Me-dC(Bz)-CE Phosphoramidite
	DMT-5Me-dC(Bz)-CE Phosphoramidite is utilized in synthesizing locked nucleic acids (LNAs) to enhance fluorescent oligonucleotide probes by optimizing their spectral properties and target affinity [1].
T83949	DC 432
	DC 432, a potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 value of 54 nM, incorporates a BM30 peptide enhanced by five arginine residues. It effectively reduces the N-terminal m...
T81348	PTZ-LD
	PTZ-LD, a phenothiazine-based fluorescent probe, specifically detects lipid droplets (LDs) with apparent emissivity (Ex/Em=488/570-620 nm) and is utilized in diabetic cataract (DC) research [1].
T75190	5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite
	5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies. Its anticancer efficacy stems from the inhibition of DNA synt...
T75226	Rev dC(Bz)-5'-amidite
	Rev dC(Bz)-5'-amidite is a purine nucleoside analog exhibiting extensive antitumor efficacy, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily mediated through the inhibition of...
T37147	5'-O-DMT-N4-Ac-dC	5'-O-DMT-N4-Ac-dC
	5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7) is a deoxynucleoside utilized in the synthesis of dodecyl phosphoramidite. Dodecyl phosphoramidite serves as a crucial precursor for dod-DNA production...